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Natural Product Research
Formerly Natural Product Letters
Volume 21, 2007 - Issue 7
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Original Articles

Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities

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Pages 600-605 | Received 24 Jan 2007, Accepted 24 Mar 2007, Published online: 20 Jun 2007
 

Abstract

Seven flavonoids named diphylloside A, epimedoside A, epimedin C, icariin, epimedoside C, icarisoside A, desmethylanhydroicaritin, as well as the oleanolic acid, were isolated from the roots of Epimedium wushanense for the first time. These flavonoids manifested significant antioxidant activity in vitro. Scavenging effects of two flavonoids were comparable to that of Vitamin C. Antibacterial experiment has shown that the diphylloside A, icarisoside A and desmethylanhydroicaritin have significant activity towards Pseudomonas aeruginosa.

Acknowledgements

We are grateful to Mr Daobao Xu, of Ankang Institute of Drug Control, for offering the plant material; to Prof. Zongdong Wang, of Luoyang Land-flora Institute of Natural Plants, for identification of the plant material. We thank the Peking Institute of Microchemistry for measurement of 1H NMR, 13C NMR and ESI MS Spectral data.

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