A new anticancer dihydroflavanoid from the root of Spiranthes australis (R. Brown) Lindl

Abstract

A new dihydroflavanoid was obtained from the root of Spiranthes australis (R. Brown) Lindl, a traditional Chinese medicinal herb. The structure was elucidated as (2S)-5,2′,6′-trihydroxy-6-lavandulyl-4″-(γ,γ-dimethylallyl)-2″,2″-dimethylpyrano-[5″,6″ : 7,8]-flavanone by spectroscopic methods including UV, IR, HR-EI-MS, ESI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activities of the compound to inhibit human cancer cells’ growth including A549, BEL-7402, SGC-7901, MCF-7, HT-29, K562, and A498 cell lines by MTT method was evaluated in vitro.

Keywords:

• Spiranthes australis (R. Brown) Lindl
• Dihydroflavanoids
• Anticancer activity

Acknowledgments

The excellent technical assistance for chemical structure elucidation from Dr Chunhui Ma (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China) is gratefully acknowledged.