Abstract
A new dihydroflavanoid was obtained from the root of Spiranthes australis (R. Brown) Lindl, a traditional Chinese medicinal herb. The structure was elucidated as (2S)-5,2′,6′-trihydroxy-6-lavandulyl-4″-(γ,γ-dimethylallyl)-2″,2″-dimethylpyrano-[5″,6″ : 7,8]-flavanone by spectroscopic methods including UV, IR, HR-EI-MS, ESI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activities of the compound to inhibit human cancer cells’ growth including A549, BEL-7402, SGC-7901, MCF-7, HT-29, K562, and A498 cell lines by MTT method was evaluated in vitro.
Acknowledgments
The excellent technical assistance for chemical structure elucidation from Dr Chunhui Ma (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China) is gratefully acknowledged.