Inhibition of human lipoprotein oxidation by morelloflavone and camboginol from Garcinia dulcis

Abstract

A biflavonoids, morelloflavone (1) and a prenyltated xanthone, camboginol (2), isolated from the fruits of Garcinia dulcis (Roxb.) Kurz., exhibited strong antioxidation effects in both Fe²⁺-mediated and non-metal induced human low-density lipoprotein (LDL) oxidations. However, a well-known antioxidant, α-tocopherol (vitamin E), was found less potent than both compounds based on the same test systems.

Keywords:

• Camboginol
• Garcinia dulcis
• Low-density lipoprotein (LDL) oxidation
• Morelloflavone

Acknowledgements

This work was financially supported in part by the grants from the Royal Thai Government and the Graduate School, Prince of Songkla University. We are also grateful to Dr. Brian Hodgson for his comments and suggestions for the revision of manuscript.