Abstract
Podophyllotoxin and related analogs present numerous challenges associated with optimal antitumor activity and severe unpredictable toxicity. In an attempt to find biorational podophyllotoxin-related drug, two moieties of podophyllotoxin have been linked at C4-position by a simple modification of the carbodiimide procedure to provide novel bispodophyllotoxin analogs (4a–4e) and their structural information was extensively characterized by using 1H-NMR, IR, and HRMS.
1For part XV: see Y.Q. Liu, L.Yang, X. Tian. Podophyllotoxin: Current Perspectives, Current Bioactive Compounds, 3 37 (2007).
Acknowledgements
This work was financially supported by the Natural Science Foundation of Gansu Province Foundation (ZGS-033-A-43-013).
Notes
1For part XV: see Y.Q. Liu, L.Yang, X. Tian. Podophyllotoxin: Current Perspectives, Current Bioactive Compounds, 3 37 (2007).