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Natural Product Research
Formerly Natural Product Letters
Volume 23, 2009 - Issue 2
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Original Articles

Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus

Ji-Won Lee Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea
,
Young-Ju Ji Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea
,
Mi-Hee Yu Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea
,
Mi-Hyang Hwang Bo Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea
,
Hwa-Jeong Seo Department of Food Science and Technology, Keimyung University, Daegu, Korea; Daegu Technopark Bio Industry Center, Daechoen-dong, Dalseo-gu, Daegu, Korea
,
Sam-Pin Lee Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea
&
In-Seon Lee Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, KoreaCorrespondence[email protected]
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Pages 101-111 | Received 13 Jun 2007, Accepted 02 Jan 2008, Published online: 29 Oct 2009
 
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Abstract

In the present study, we investigated antimicrobial activity of Glycyrrhiza uralensis against various strains of methicillin-resistant Staphylococcus aureus (MRSA) (KCCM 11812, 40510, 40512). Glycyrrhiza uralensis was extracted by 80% MeOH and fractionated by organic solutions. The extract and fractions showed antimicrobial activity against standard S. aureus as well as MRSA. In the minimum inhibitory concentration test, G. uralensis showed 0.25 mg mL−1 in hexane fraction and 0.10–0.12 mg mL−1 in chloroform fraction. Especially, chloroform fraction showed 2.5 times higher antimicrobial activity than penicillin. Furthermore, chloroform fraction correlated with MRSA gene expression (MecA, MecI, MecRI, FemA). These results suggest that G. uralensis may have potent antimicrobial activity and thus, this medicinal herb can be a suitable phytotherapeutic agent for treating MRSA infections.

Acknowledgements

This work was supported by the Ministry of Commerce, Industry and Energy (MOCIE) through the Center for Traditional Microorganism Resources (TMR) at Keimyung University, Republic of Korea.

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