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Natural Product Research
Formerly Natural Product Letters
Volume 22, 2008 - Issue 12
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Original Articles

Anticarcinogenic and antimitotic effects of Turkish propolis and mitomycin-C on tissue cultures of bladder cancer

Halil Erhan Eroğlu Department of Biology, Faculty of Science and Art, University of Bozok, Yozgat, TurkeyCorrespondence[email protected]
,
Yusuf Özkul Department of Medical Genetics, Faculty of Medicine, University of Erciyes, Kayseri, Turkey
,
Atilla Tatlısen Department of Urology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey
&
Sibel Silici Department of Animal Health, Safiye Cikrikcioglu Vocational College, University of Erciyes, 38039, Kayseri, Turkey
Pages 1060-1066 | Received 20 Jan 2008, Accepted 02 Jul 2008, Published online: 10 Sep 2008
 
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Abstract

The in vitro anticarcinogenic and antimitotic effects of propolis and mitomycin-C (MMC) on transitional carcinoma cell cultures were investigated. Tissue samples were obtained from 22 patients with bladder carcinomas, which were exposed to propolis (0.1 mL) and MMC (1.6 µL). The mean MI rates for control, propolis and MMC were 8.327 ± 0.624, 6.990 ± 0.519 and 5.423 ± 0.479, respectively. The differences between the control and exposed cells were significant (p < 0.05). We conclude that exposure to propolis can decrease cell division and it may be used as an antimitotic and anticarcinogenic agent.

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