Effect of successive increase in alcohol chains on reaction with isocyanates and isothiocyanates

Abstract

The reaction of isocyanates and isothiocyanates with long-chain alcohols, e.g. n-hexanol, n-heptanol and n-octanol, exclusively gave N-aryl-O-alkyl carbamates, while N-aryl-O-alkyl carbamates were formed along with symmetrical 1,3-disubstituted ureas and thioureas when the same reactions were carried out with small-chain alcohols at room temperature without using any solvent.

Keywords:

• alcohols
• isocyanates
• isothiocyanates
• N-aryl-O-alkyl carbamates
• symmetrical ureas

Acknowledgements

The authors are thankful to the Pakistan Science Foundation ‘PSF Grants for Active Scientists and Technologists of Pakistan’ for funding for this research work.