Microsphaeropsisin A, a new sesquiterpenoid isolated from the mangrove endophytic fungus (No. DZ39)

Abstract

A new sesquiterpenoid compound, microsphaeropsisin A (1), together with three known dihydroisocoumarin compounds, (R)-mellein (2), 4-hydroxymellein (3) and 5-hydroxymellein (4) were isolated from the culture of the mangrove fungus (No. DZ39). The structure of the new compound was established by comprehensive spectral analysis, especially 2D NMR spectroscopy.

Keywords:

• marine fungi
• secondary metabolite
• microsphaeropsisin A

Acknowledgements

We wish to acknowledge financial support from the National Natural Science Foundation of China (40776073, 20072058), the 863 Foundation of China (2003AA624010), the Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China (No. 706038), the Program for New Century Excellent Talents in University, Ministry of Education of China (No. NCET-05-0600), the Natural Science Foundation of Guangdong province, China (021732), the doctoral startup fund of the Ocean University of China (1404-82421036), Syngenta Limited in the UK and the Star Lake Biotechnology Co., Inc., Zhaoqing, Guangdong, China.