Abstract
The synthesis of the marine natural products pyridinebetaine A and B is reported. The biological evaluation of pyridinebetaine A and B and several analogues as cytotoxic, antifungal and antiviral agents is also described. Unfortunately, none of the compounds tested showed relevant antifungal or cytotoxic activity. Only pyridinebetaine B reduced the Herpes simplex virus type 1 virus replication, though only weakly.
Acknowledgements
Financial support from the Spanish Ministry of Science and Education, under a ‘Ramón y Cajal’ research grant, and also from the Generalitat Valenciana (project GV/2007/007), is gratefully acknowledged. Liliana Betancur-Galvis thanks the financial support of the Antioquia University of Colombia.