Two new geranyl flavanones from Tephrosia villosa

Abstract

Two new geranyl flavanones, (2S)-5,4′-dihydroxy-7-O-[(E)-3,7-dimethyl-2,6-octadienyl]flavanone (1) and (2S)-5,4′-dihydroxy-7-O-[(E)-3,7-dimethyl-2,6-octa-dienyl]-8-C-[(E)-3,7-dimethyl-2,6-octadienyl]flavanone (2), together with three known compounds, 7-O-methylglabranin (3), tephcalostan (4) and 12a-dehydro-6-hydroxysumatrol (5), were isolated from the roots of Tephrosia villosa. The structures of these compounds were determined by extensive spectral studies.

Keywords:

• Tephrosia villosa
• Leguminosae
• geranyl flavanones

Acknowledgements

The authors are grateful to Dr Arul Marie and Mr Dubost Lionel, Laboratoire de Chimie et Biochimie des Substances Naturelles, MNHN, Paris, France for providing mass spectral data, and Dr M.M. Murthy, Indian Institute of Chemical Technology, Hyderabad, India for providing CD spectral data.