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Natural Product Research
Formerly Natural Product Letters
Volume 25, 2011 - Issue 1
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Research Articles

Isoswertisin flavones and other constituents from Peperomia obtusifolia

Jonas da S. Mota Instituto de Química, Universidade Estadual Paulista, CP 355, CEP 14801-970, Araraquara, SP, Brazil
,
Ana C. Leite Instituto de Química, Universidade Estadual Paulista, CP 355, CEP 14801-970, Araraquara, SP, Brazil
,
Massuo J. Kato Instituto de Química, Universidade de São Paulo, CP 26077, 05599-970 São Paulo, SP, Brazil
,
Maria Claudia M. Young Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, CP 4005, CEP 01061-970, São Paulo, SP, Brazil
,
Vanderlan da S. Bolzani Instituto de Química, Universidade Estadual Paulista, CP 355, CEP 14801-970, Araraquara, SP, Brazil
&
Maysa Furlan Instituto de Química, Universidade Estadual Paulista, CP 355, CEP 14801-970, Araraquara, SP, BrazilCorrespondence[email protected]
Pages 1-7 | Received 05 Jun 2009, Accepted 02 Sep 2009, Published online: 13 Jan 2011
 
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Abstract

A phytochemical investigation of the leaves and stems of Peperomia obtusifolia (Piperaceae) yielded a new flavone C-diglycoside isoswertisin-4′-methyl-ether-2″α-L-rhamnoside (1), along with four known compounds: isoswertisin-2″α-L-rhamnoside (2), (+)-diayangambin (3), 2-episesalatin (4) and corchoionoside C (5). The structures of the two flavone C-diglycosides (1, 2) were elucidated on the basis of 1D and 2D NMR spectroscopy and MS spectrometric data. These flavones were evaluated by bioautographic assay against Cladosporium cladosporioides and C. sphaerospermum and showed weak antifungal activity.

Acknowledgements

The authors thank the financial support provided by FAPESP within the BIOTA/FAPESP – The Biodiversity Virtual Institute Program (www.biotasp.org.br). M.J. Kato, Vanderlan da S. Bolzani and M. Furlan are grateful to CNPq for research fellowships.

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