Abstract
This work reports the isolation of the sesquiterpene lactone 15-deoxygoyazensolide from the stems of Minasia alpestris and the evaluation of its antimicrobial activity against the following oral pathogens: Enterococcus faecalis, Streptococcus salivarius, Streptococcus sobrinus, Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, and Lactobacillus casei. Despite the cytotoxicity and genotoxicity of other sesquiterpene lactones of the furanoheliangolide-type, our results revealed that this compound exhibits low antibacterial activity against the evaluated oral pathogens; however, an interesting selectivity against E. faecalis (minimum inhibitory concentration [MIC] = 40 µg mL−1) and S. sobrinus (MIC = 60 µg mL−1) was observed.
Acknowledgements
We are grateful to Prof. Norberto P. Lopes (FCFRP-USP) and Prof. João L.C. Lopes (FCFRP-USP) for their support to this work. The authors thank the Brazilian foundations FAPESP (Process 07/54241-8) and CAPES for financial support.