A new steroidal glycoside from the Ophiopogon japonicus Ker-Gawler (Liliaceae)

Abstract

A new steroidal glycoside (1), (25R)-14α, 17α-hydroxyspirost-5-en-3β-yl 3-O-α-L-rhamnpyranosyl-(1 → 2)-β-D-glucopyranosyl-(1 → 3)-β-D-glucopyranoside, together with three known steroidal glycosides, (25R)-3β-hydroxyspirost-5-en-1β-yl-3-O-α-L-rhamnopyranosyl-(1 → 2)-O-β-D-xylopyranosyl-(1 → 3)-α-L-arabinopyranoside (2), Cixi-ophiopogon B (3) and Cixi-ophiopogon A (4), were obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae). Compound 2 was isolated from the Ophiopogon genus for the first time. Their structures were identified on the basis of extensive mass and nuclear magnetic resonance spectroscopic analysis.

Keywords:

• Ophiopogon japonicus
• Liliaceae
• steroidal glycoside
• ophiogenin

Acknowledgements

This work was supported by the Program for New Century Excellent Talents in University (NCET-06-0515) and National S&T Major Projects (2008ZX09202-006 and 2009ZX09313-036).