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Natural Product Research
Formerly Natural Product Letters
Volume 25, 2011 - Issue 4
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Research Articles

Anti-allergic effect of the flavonoid myricitrin from Myrica rubra leaf extracts in vitro and in vivo

Shunsuke Shimosaki Department of Cooperative Medical Research, Collaboration Center, Shimane University, Izumo 693–8501, Japan
,
Yoko Tsurunaga Faculty of Human Science, Hiroshima Bunkyo Women's University, Hiroshima 731–0295, Japan
,
Hiroyuki Itamura Faculty of Life and Environmental Science, Shimane University, Matsue 690–8504, Japan
&
Morihiko Nakamura Department of Cooperative Medical Research, Collaboration Center, Shimane University, Izumo 693–8501, JapanCorrespondence[email protected]
Pages 374-380 | Received 09 Dec 2009, Accepted 13 Mar 2010, Published online: 13 Feb 2011
 
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Abstract

Flavonoids are ingested by the general population as anti-oxidant and anti-inflammatory agents. In this study, we investigated the effects of myricitrin, a flavonoid rich in Myrica rubra leaf, upon anti-inflammatory action. Myrica rubra leaf extracts inhibited pro-inflammatory TNFα production in a macrophage cell line, Raw264.7 cells. We observed that the serum IgE levels in the leaf extract-treated DO11.10, a mouse allergy model, were down-regulated. HPLC was performed to demonstrate that M. rubra leaf extracts contain a large amount of myricitrin. We observed an inhibitory effect of HPLC-purified myricitrin on TNFα production in Raw264.7 cells. Thus, myricitrin may be of potential interest in the management of inflammatory conditions.

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