Four new polyoxygenated gorgosterols from the gorgonian Isis hippuris

Abstract

Four new polyoxygenated steroids (1–4) together with four known ones (5–8) have been isolated from the gorgonian Isis hippuris. The structures of the new compounds have been elucidated by spectroscopic analysis and chemical conversion. All of the new steroids showed moderate cytotoxicity against cultured NBT-T2 cells.

Keywords:

• polyoxygenated steroids
• gorgosterol
• NBT-T2
• cytotoxicity

Acknowledgements

This work was supported in part by the twenty-first century COE programme from the University of Ryukyus and grant-in-aid (no. 18032061) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.