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Natural Product Research
Formerly Natural Product Letters
Volume 25, 2011 - Issue 12
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Short Communications

Antifungal activity of sakurasosaponin from the root extract of Jacquinia flammea

K. García-Sosa Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No. 130 Col. Chuburná de Hidalgo, Mérida, Yucatán, 97200 México
,
A. Sánchez-Medina The Medicines Research Group, School of Health and Bioscience, University of East London, University House, Ramford Road, London, E15 ALZ, UK
,
Sandra L. Álvarez Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
,
S. Zacchino Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
,
N.C. Veitch Jodrell Laboratory, Royal Botanic Gardens, Kew, Surrey, TW9 3AB, UK
,
P. Simá-Polanco Unidad de Recursos Naturales, Centro de Investigación Científica de Yucatán, Calle 43 No. 130 Col. Chuburná de Hidalgo, Mérida, Yucatán, 97200 México
&
L.M. Peña-Rodriguez Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No. 130 Col. Chuburná de Hidalgo, Mérida, Yucatán, 97200 MéxicoCorrespondence[email protected]
 show all
Pages 1185-1189 | Received 27 Nov 2009, Accepted 20 Jun 2010, Published online: 11 Jul 2011
 
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Abstract

The methanolic crude extract from the roots of Jacquinia flammea showed moderate antifungal activity against dermatophytes and very strong antifungal activity against Colletotrichum gloeosporioides. The bioassay-guided purification of the extract, using a combination of vacuum-liquid chromatography and high performance liquid chromatography, allowed the identification of sakurasosaponin (1) as the main metabolite responsible for the antifungal activity.

Acknowledgements

The authors thank Alejandra Rodríguez Luna and Rosa Lidia Solís Oviedo for technical assistance. This study was supported by Program CYTED (Project X.7) and Project FOMIX-Yucatán (66262).

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