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Natural Product Research
Formerly Natural Product Letters
Volume 26, 2012 - Issue 11
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Research Articles

Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba

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Pages 979-986 | Received 26 Apr 2010, Accepted 11 Sep 2010, Published online: 11 Aug 2011
 

Abstract

The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC50 values of 0.76 and 0.83 µg mL−1, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.

Acknowledgements

This study was supported by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, (2009-0094061) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0341).

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