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Natural Product Research
Formerly Natural Product Letters
Volume 26, 2012 - Issue 11
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Research Articles

Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine

Bina S. Siddiqui H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, PakistanCorrespondence[email protected]
,
Syed Tahir Ali Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
,
Ghazala H. Rizwani Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
,
Sabira Begum H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
,
Saima Tauseef Department of Microbiology, University of Karachi, Karachi-75270, Pakistan
&
Aqeel Ahmad Department of Microbiology, University of Karachi, Karachi-75270, Pakistan
Pages 987-992 | Received 28 Oct 2009, Accepted 20 Oct 2010, Published online: 11 Aug 2011
 
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Abstract

The antimicrobial activity of the methanolic extract of the bark of Holarrhena pubescens, its fractions, and conessine, a steroidal alkaloid, was determined against various bacteria and fungi using the agar diffusion method. They were all found to possess significant activity against some of the bacteria tested. The alkaloidal fraction and conessine also exhibited marginal activity against some of the fungi tested. The minimum inhibitory concentration (MIC) value of conessine was determined against various bacteria, and the highest activity was seen against Micrococcus luteus ATCC 9341 (MIC: 15.6 µg per disc).

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