Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 26, 2012 - Issue 11
172
Views
9
CrossRef citations to date
0
Altmetric
Short Communications

Antidiarrhoeal and bronchodilatory potential of Valeriana wallichii

&
Pages 1045-1049 | Received 26 Oct 2010, Accepted 30 Dec 2010, Published online: 20 Oct 2011
 

Abstract

This study describes the antidiarrhoeal and bronchodilatory activities of Valeriana wallichii D.C. (Valerianaceae). The crude extract of V. wallichii (Vw.Cr) caused inhibition of castor oil-induced diarrhoea in mice at 300–600 mg kg−1. In guinea-pig trachea, Vw.Cr concentration dependently (0.03–3.0 mg mL−1) relaxed the low K+ (25 mM)-induced contractions, with a mild effect on the contractions induced by high K+ (80 mM). In the presence of glibenclamide, the relaxation of low K+-induced contractions was prevented. Similarly, cromakalim caused glibenclamide-sensitive inhibition of low K+, without any effect on high K+. These results indicate that V. wallichii exhibits antidiarrhoeal and bronchodilatory activities, possibly through K+ channel activation, and thus reveal its medicinal usefulness in hyperactive gut and airway disorders such as diarrhoea and asthma.

Acknowledgement

This study was supported in part by funds made available by the Pakistan Science Foundation.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.