A new diphenyl ether from Phoma sp. strain, SHZK-2

Abstract

A new diphenyl ether methyl 2-(2-formyl-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxybenzoate (3), together with four known compounds, asterric acid (1), methyl asterrate (2), 9(Z),12(Z)-nonadecadienoic acid (4) and orsellinic acid (5), were isolated from the Phoma sp. strain SHZK-2, which was isolated from a polluted environment in southern China. The structures of these compounds were determined by spectroscopic methods. Cytotoxicities of compounds against HEPG2 cell and Raji cell lines were preliminarily evaluated by the MTT method.

Keywords:

• Phoma sp.
• secondary metabolites
• diphenyl ether
• asterric acid
• cytotoxicity

Acknowledgements

The authors would like to thank the financial supports from the Foundation of Xiamen University (No. 0070Z03134) and the Natural Science Foundation of Fujian Province of China (No. 2009J01192).