Antithrombotic lipids from Semen Persicae

Abstract

Chemical investigation of Semen Persicae has led to the isolation of decane (1), triolein (2), nonacosanoic acid (3), oleic acid ethyl ester (4), palmitic acid (5), oleic acid (6) and 15,16-dihydroxy-9Z,12Z-octadecadienoic acid 2,3-dihydroxypropyl ester (7). Amongst these, compound 7 is a new lipid. Their structures were elucidated by chemical and extensive spectral analysis. Their anticoagulative activities were also evaluated in vitro, which showed that petroleum ether extract and compounds 5–6 could significantly prolong thrombin time while methanol extract could obviously inhibit platelet aggregation.

Keywords:

• Semen Persicae
• Prunus persica
• fatty acid
• antithrombotic activity

Acknowledgements

This research study was financially supported by 2006 Great Basic Science Research Project of Jiangsu College and University (no. 06KJA36022), Construction Project for Jiangsu Key Laboratory for High Technology Research of TCM Formulae (BM 2010576) and Construction Project for Jiangsu Engineering Center of Innovative Drug from Blood-Conditioning TCM Formulae, which are gratefully acknowledged.

Notes

Joint first authors

Additional information

Notes on contributors

Li Liu

Joint first authors