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Research Articles

Antioxidant and lipoxygenase inhibiting new iridoid glucosides from Caryopteris odorata

, , , , , , , & show all
Pages 302-313 | Received 13 Sep 2011, Accepted 25 Dec 2011, Published online: 16 Mar 2012
 

Abstract

The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (14): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-cafeoyl massenoside (4). The structures of these compounds were determined by FAB-MS, IR, 1D and 2D-NMR spectroscopy and by comparing with the published data of the closely related compounds. The antioxidant potential of the isolated iridoids (14) was evaluated relative to conventionally used standards and these molecules exhibited good antioxidant potential. Moreover, their inhibitory potential was also screened against three enzymes, namely acetyl cholinesterase, butyrylcholinesterase and lipoxygenase. These iridoid glucosides were found to be inactive against acetyl and butyrylcholinesterases but active against lipoxygenase.

Acknowledgements

The authors are thankful to the Higher Education Commission of Pakistan for providing financial grant for this study. The authors appreciate Prof. Atta-ur-Rahman, FRS, for his contributions to Higher Education in Pakistan and OIC countries

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