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Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 4-5: Special Issue in Honour of Professor Atta-Ur-Rahman
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Short Communications

Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis

Joaquim S. Costa Júnior Departamento de Química, Instituto Federal do Piauí, PI 64000-040, Teresina, Brasil
,
Antonia Amanda Cardoso de Almeida Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil
,
Alexandre de Barros Falcão Ferraz Laboratório de Genética Toxicológica, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, RS 92425-900, Canoas, Brasil
,
Raíssa Rebés Rossatto Laboratório de Genética Toxicológica, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, RS 92425-900, Canoas, Brasil
,
Teresinha G. Silva Departamento de Antibióticos, Universidade Federal de Pernambuco, PE 50670-901, Recife, Brasil
,
Paulo B.N. Silva Departamento de Antibióticos, Universidade Federal de Pernambuco, PE 50670-901, Recife, Brasil
,
Gardenia C.G. Militão Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, PE 50670-90, Recife, Brasil
,
Antonia Maria das Graças Lopes Citó Departamento de Quimica, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil
,
Lorena Citó Lopes Resende Santana Departamento de Bioquimica e Farmacologia, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil
,
Fernando Aécio de Amorim Carvalho Departamento de Bioquimica e Farmacologia, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil
&
Rivelilson M. Freitas Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil; Departamento de Bioquimica e Farmacologia, Universidade Federal do Piauí, PI 64049-550, Teresina, BrasilCorrespondence[email protected]
 show all
Pages 470-474 | Received 17 Nov 2011, Accepted 02 May 2012, Published online: 18 Jun 2012
 
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Abstract

Garcinielliptone FC (GFC), a natural prenylated benzophenone, was extracted from Platonia insignis Mart. (Clusiaceae), a native plant commonly known as bacuri and used in traditional Brazilian medicine for the treatment of skin diseases. The aim of this study was to evaluate the cytotoxic and leishmanicidal effects of GFC using in vitro models. The experimental data demonstrated that the polyisoprenylated benzophenone GFC possesses cytotoxic and leishmanicidal activities.

Acknowledgements

This study was supported by CNPq, IFPI, and FAPEPI through grants and fellowships.

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