Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai

Abstract

Phytochemical investigation of Hypericum nakamurai (Masamune) Robson has led to the isolation of three phloroglucinol derivatives 1–3. The structures of these compounds were determined by the analysis of their spectroscopic data (IR, mass and UV), and by the application of 1-D and 2-D-NMR techniques. Hyperinakin (1) is a new compound. The anti-inflammatory activities of compounds 1–3 were also tested and evaluated. A biogenetic pathway for compounds 1–3 was also proposed.

Keywords:

• Hypericum nakamurai
• phloroglucinols
• anti-inflammatory activity

Acknowledgement

The authors thank the National Science Council, Republic of China (NSC-95-2320-B-002-118-MY3) for providing financial support.