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Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 9
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Research Article

Two new diterpenes from Caesalpinia minax Hance

Guo-Xu Ma Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
,
Jing-Quan Yuan Guangxi Botanical Garden of Medical Plant, Nanning 530023, China
,
Li Cao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
,
Jun-Shan Yang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
&
Xu-Dong Xu Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaCorrespondence[email protected]
Pages 818-823 | Received 23 Feb 2012, Accepted 22 Jun 2012, Published online: 19 Jul 2012
 
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Abstract

Two new cassane-type diterpenes, Caesalpinolide F (1) and Caesalpinolide G (2) were isolated from Caesalpinia minax Hance. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analysis. Compounds 1 and 2 were tested against colon carcinoma (HCT-8) and breast cancer (MCF-7) human cancer cell lines, and showed mild cytotoxicity activities.

Acknowledgements

The work was supported by the technological large platform for comprehensive research and development of new drugs in the Eleventh Five-Year ‘Significant New Drugs Created’ Science and Technology Major Projects (No. 2009ZX09301-003). National Natural Science Foundation of China (No. 30 973 626), the Science and Technology Grant of Guangxi Province (No. 0 639 039) and special purpose of basic scientific research operation grant for Commonweal Academy and Institute of Central Authorities (No. YZ-1-24). Innovation capacity-building in Guangxi Science and Technology Agency (0443002-2).

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