A new bergenin derivative from the rhizome of Ardisia gigantifolia

Abstract

One new bergenin derivative, named 11-O-veratroylbergenin (1) along with five known bergenin derivatives, 11-O-(3′-O-methylgalloyl) bergenin (2), 11-O-syringylbergenin (3), 11-O-Galloylbergenin (4), 4-O-Galloylbergenin (5) and bergenin (6) were isolated from Ardisia gigantifolia Stapf. Their structures were established on the basis of spectroscopic analysis, especially by means of 1D, 2D-NMR and HR–ESIMS analyses. Compounds 2, 4 and 5 showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity with EC₅₀ 9.7, 9.0 and 7.8 µmol L⁻¹, respectively. They showed more antioxidant activity than the positive control vitamin C (EC₅₀ = 28.3 µmol L⁻¹).

Keywords:

• Ardisia gigantifolia
• bergenin derivatives
• antioxidant activity

Acknowledgements

This study was supported by National Nature Science Foundation of China (no. 31000153). We are grateful to Mr Li-Ping Kang for the NMR and HR–ESI–MS measurement in the Instrumentation Center of the Academy of Military Medical Sciences.

Notes

This author contributed equally to this study.

Additional information

Notes on contributors

Ju-Qiang Feng

This author contributed equally to this study.