A new taurine derivative from South China Sea marine sponge Axinella sp.

Abstract

A new (1) and two known (2 and 3) acylated taurine derivatives were isolated from the South China Sea marine sponge Axinella sp. The structures of the compounds were determined on the basis of spectral analysis. Compounds 1–3 did not inhibit the growth of hepatoma carcinoma cell (HepG2), lung carcinoma cell (A549), human breast carcinoma (MCF-7), no-small cell lung cancer (NCI-H460) and human nasopharyngeal carcinoma cell lines.

Keywords:

• marine sponges
• Axinella sp.
• taurine derivatives

Acknowledgements

This study was supported by grants from National Natural Science Foundation of China (Nos. 40706046, 30973679 and 31100260), Knowledge Innovation Program of Chinese Academy of Sciences (KSCX2-EW-J-28), the Program of Guangzhou City (No. 12C14061559), the Program of South China Botanical Garden (No. 201037), the Foundation of Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences (Nos. 201210ZS and 211012).