Three new steroid glycosides from the starfish Asterina pectinifera

Abstract

Three new steroid glycosides, pectiniosides H–J (1–3), were isolated along with three known compounds (4–6) including a steroid glycoside and two polyhydroxysteroids, from the alcoholic extract of the starfish Asterina pectinifera. The structures of 1–3 were determined by extensive NMR and HR-ESI-MS experiments. Compounds 1–4 did not show cytostatic activity on HL-60 cells below 100 μM, while compounds 5–6 showed moderate cytostatic activity, with IG50 values of 80.3 and 40.5 μM, respectively.

Keywords::

• steroid glycosides
• pectinioside
• polyhydroxysteroids
• starfish
• Asterina pectinifera

Acknowledgement

This work was supported by Ph.D. Startup Foundation of Liaoning Province, China (20121105).