New dipyranocoumarin from the leaves of Calophyllum apetalum Willd

Abstract

A new dipyranocoumarin, α-hydroxytomentolide A (1) was isolated from the leaves of Calophyllum apetalum together with the known compounds friedelin (2), apetalactone (3), inophyllum C (4) and canophyllol (5). The structure of the new compound was established by spectroscopic studies which include ¹H NMR, ¹³C NMR, NOESY, HetCOSY, COLOC experiments and single crystal X-ray diffraction analysis.

Keywords::

• Calophyllum apetalum
• Guttiferae
• dipyranocoumarins
• α-hydroxytomentolide A
• triterpenoids

Acknowledgements

This work was supported by Indian Council of Medical Research, New Delhi. We thank Botanical Survey of India, Western Circle, Pune for authentication of plant material.