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Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 20
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Research Article

A new isobenzofuranone from the mangrove endophytic fungus Penicillium sp. (ZH58)

Jianxiang YangLaboratory of Natural Product Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, P.R. China;School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P.R. ChinaCorrespondence[email protected] [email protected]
,
Riming HuangLaboratory of Natural Product Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, P.R. China
,
Sheng Xiang QiuLaboratory of Natural Product Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, P.R. China
,
Zhigang SheSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P.R. China
&
Yongcheng LinSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P.R. China
Pages 1902-1905 | Received 20 Dec 2012, Accepted 19 Feb 2013, Published online: 12 Apr 2013
 
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Abstract

A new isobenzofuranone, 4-(methoxymethyl)-7-methoxy-6-methyl-1(3H)-isobenzofuranone (1), together with seven known compounds, dilation (2), lumichrome (3), curvulari (4), 5,5′-oxy-dimethylene-bis(2-furaldehyde) (5), chromone (6), harman(1-methyl-β-carboline) (7), N9-methyl-1methyl-β-carboline (8), was isolated from the mangrove endophytic fungus, Penicillium sp. ZH58 obtained from the South China Sea coast. Their structures were determined by analysis of spectroscopic data. Compound 1 exhibited cytotoxicity against KB and KBV200 cells with IC50 values of 6 and 10 μg/mL, respectively.

Acknowledgements

This research was supported by the National Natural Science Foundation of China (20772162, 20972197, 31100260), the 863 Foundation of China (2007AA09Z448, 2006AA09Z422), the National Science Foundation of Guangdong Province, China (9151027501000055), the Knowledge Innovation Programme of Chinese Academy of Sciences (KSCX2-EW-J-28), the Programme of Guangzhou City (No. 12C14061559) and the Department of Education Scientific Research project of Guangxi Province (201204LX497).

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