Abstract
A new isobenzofuranone, 4-(methoxymethyl)-7-methoxy-6-methyl-1(3H)-isobenzofuranone (1), together with seven known compounds, dilation (2), lumichrome (3), curvulari (4), 5,5′-oxy-dimethylene-bis(2-furaldehyde) (5), chromone (6), harman(1-methyl-β-carboline) (7), N9-methyl-1methyl-β-carboline (8), was isolated from the mangrove endophytic fungus, Penicillium sp. ZH58 obtained from the South China Sea coast. Their structures were determined by analysis of spectroscopic data. Compound 1 exhibited cytotoxicity against KB and KBV200 cells with IC50 values of 6 and 10 μg/mL, respectively.
Acknowledgements
This research was supported by the National Natural Science Foundation of China (20772162, 20972197, 31100260), the 863 Foundation of China (2007AA09Z448, 2006AA09Z422), the National Science Foundation of Guangdong Province, China (9151027501000055), the Knowledge Innovation Programme of Chinese Academy of Sciences (KSCX2-EW-J-28), the Programme of Guangzhou City (No. 12C14061559) and the Department of Education Scientific Research project of Guangxi Province (201204LX497).