Abstract
Four indanomycin-related antibiotics 2–5 were isolated from the cultured broth of marine Streptomyces antibioticus strain PTZ0016. Their structures were characterised as 16-deethylindanomycin (2), iso-16-deethylindanomycin (3), 16-deethylindanomycin methyl ester (4) and iso-16-deethylindanomycin methyl ester (5) on the basis of NMR, HR-ESI-MS and CD evidences. Compounds 3–5 are new additions to the class of indanomycin antibiotics. All isolated compounds showed in vitro activity against Staphylococcus aureus with minimal inhibitory concentration at 4.0–8.0 μg/ml.
Acknowledgements
This work was supported by grants from the National Science Foundation of China (no. 81273428) and the Cross-Disciplinary Research for Ocean Science of Zhejiang University (no. 2012HY018B).