A new biphenyl and other constituents from the wood of Garcinia schomburgkiana

Abstract

A new biphenyl, named schomburgbiphenyl (1), and 14 known compounds were isolated from the wood of Garcinia schomburgkiana. The known constituents were identified as follows: three xanthones (2, 8 and 9), two benzophenones (3 and 4), three biphenyls (5–7), three biflavonoids (10–12) and three steroids. Compounds 3 and 4 were highly cytotoxic to SW620 cell line (100 times more than the positive control, doxorubicin) and were also strongly active against KATO-III, HepG2 and CHAGO cell lines. Compound 6 was specifically cytotoxic towards SW620 cells, whereas compound 8 displayed strong cytotoxicity against all five cell lines tested.

Keywords::

• Garcinia schomburgkiana
• schomburgbiphenyl
• biphenyl
• benzophenone
• xanthone
• cytotoxicity

Acknowledgements

This work was financially supported by a grant from the Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand. The authors are grateful to Assoc. Prof. Ing-On Mondranondra for providing and identifying the plant material.