Two new withanolides from the halophyte Datura stramonium L.

Abstract

Eight steroids, including five withanolides (1–5) and three other ergostane-type steroids (6–8), were isolated from the aerial parts of the halophyte Datura stramonium L., which were collected from the Yellow River Delta in China. Their structures were elucidated on the basis of extensive spectroscopic methods, especially 1D and 2D NMR techniques. Compounds 1 and 2 were new compounds and characterised as (22R)-27-hydroxy-7α-methoxy-1-oxowitha-3,5,24-trienolide and its 27-O-β-d-glucopyranoside. Compound 3 was a new natural product and identified as (22R)-27-hydroxy-1-oxowitha-2,5,24-trienolide and isolated from nature for the first time.

Keywords::

• Datura stramonium
• halophyte
• withanolides
• steroids