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Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 23
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Articles

Novel antimicrobial metabolites produced by Sika deer-associated Actinomyces sp. JN411010

Yujiao TangChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Yanmei WangChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Zhaohui WangJilin Agricultural University, Changchun, 130118, P.R. China
,
Jing ZhangChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Jianchun QinCollege of Plant Sciences, Jilin University, Changchun, 130062, P.R. China
,
Quankai WangChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Lihua YangChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Lingzhi XuChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Yuling DingChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Yang GuoChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Hongliang LiChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Jingsi LiChina–Korea Joint Institute for Animal Science of Jilin Province, Changchun, 130600, P.R. China
,
Guangzhi SunJilin Agricultural University, Changchun, 130118, P.R. ChinaCorrespondence[email protected]
&
Wenchong LiuJilin Agricultural University, Changchun, 130118, P.R. China
 show all
Pages 2183-2189 | Received 26 Jan 2013, Accepted 02 May 2013, Published online: 16 Jul 2013
 
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Abstract

Three novel metabolites (1, 5 and 10) were isolated from a 25-L fermentation broth of Actinomyces sp. JN411010 together with 11 related compounds. Their structures were determined on the basis of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data analyses. Compounds 1–2, 5–8 and 10 displayed moderate antimicrobial activities against Gram-positive and Gram-negative bacteria. Biosynthetic pathway of 5 and 10 was proposed to be catalysed by polyketide and non-ribosomal peptide gene clusters, respectively.

Acknowledgements

This work was partially supported by Chinese Sika deer standardised system and product development of key technical project (2011DFA32900, Ministry of Science and Technology of the People's Republic of China) and funded by Jilin China–Korea Joint Institute for Animal Science. We are grateful to Dr Jingwei Xu from National Analytical Research Center of Electrochemistry and Spectroscopy for supplying the NMR spectra.

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