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Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 21
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Research Article

Zantholic acid, a new monoterpenoid from Zanthoxylum zanthoxyloides

N.A. Vyry WouatsaCSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, India;Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, India
,
L.N. MisraCSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, IndiaCorrespondence[email protected]
,
R. Venkatesh KumarBabasaheb Bhimrao Ambedkar University, Lucknow, 226025, India
,
Mahendra P. DarokarCSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, India
&
Francois TchoumbougnangInstitute of Fisheries Sciences, University of Douala, Douala, 24157, Cameroon
Pages 1994-1998 | Received 10 Feb 2013, Accepted 22 May 2013, Published online: 26 Jun 2013
 
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Abstract

From the extract of Zanthoxylum zanthoxyloides fruits, a new menthane monoterpenoid, (4R,7R)-8-carboxy-7,9-dihydroxy-trans-menthane, tentatively, named as zantholic acid along with several known compounds was isolated. Its structure was determined using spectroscopic methods. The cytotoxic activity of zantholic acid against a panel of cancer cell lines was evaluated using the MTT assay. The results show that zantholic acid possesses a selective cytotoxic activity towards breast cancer cell lines.

Acknowledgements

TWAS and CSIR are acknowledged for the award of a fellowship to Ms N.A. Vyry Wouatsa. The Director of CIMAP is thanked for providing the research facilities and encouragement.

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