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Abstract
A new minor quassinoid named bruceine M (1), together with 12 known quassinoids (2–13), was isolated from the fruits of Brucea javanica (Simaroubaceae). Their structures were determined by interpretation of NMR and HR-ESI-MS data. The structures of the known compounds were confirmed by comparison of their spectral data with those reported in the literatures. In vitro cytotoxicity of the isolated compounds against cancer cell lines Bel-7404, MCF-7 and A549 was evaluated. Compounds 4, 6 and 9 exhibited significant growth inhibitory activity against three cancer cell lines.
Acknowledgements
This work was jointly supported by grants from Chinese Academy of Sciences 100 Talents Program Endowment award to SXQ, the National and Guangdong Province Natural Science Foundation of China (Nos 30973635 and 10151065005000026), the Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-YW-R-217), National Science and Technology Major Project (No. 2009ZX09103-414) and Guangzhou Municipal Science and Technology Major Project (Nos 2009A1-E011 and 2010ul-E00531).