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Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 21
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Research Article

A new pentacyclic triterpenoid from the leaves of Lantana montevidensis (Spreng.) Briq.

Makboul A. MakboulFaculty of Pharmacy, Pharmacognosy Department, Assiut University, Assiut, 71526, Egypt
,
Ahmed A. AttiaFaculty of Pharmacy, Pharmacognosy Department, Assiut University, Assiut, 71526, Egypt
,
Salwa F. FaragFaculty of Pharmacy, Pharmacognosy Department, Assiut University, Assiut, 71526, EgyptCorrespondence[email protected]
,
Nesma M. MohamedFaculty of Pharmacy, Pharmacognosy Department, Assiut University, Assiut, 71526, Egypt
,
Samir A. RossNational Center for Natural Products Research;Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, Mississippi38677-1848, USA
,
Yoshiaki TakayaFaculty of Pharmacy, Meijo University, TempakuNagoya468-8503, Japan
&
Masatake NiwaFaculty of Pharmacy, Meijo University, TempakuNagoya468-8503, Japan
 show all
Pages 2046-2052 | Received 07 Feb 2013, Accepted 04 Jun 2013, Published online: 21 Aug 2013
 
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Abstract

A new pentacyclic triterpenoid, 3β,25-epoxy-3α,22β,23α-trihydroxy-olean-12-en-28-oic acid (1), together with seven known compounds, including five triterpenoids, β-amyrin (2), lantadene B (3), lantanilic acid (4), lantanolic acid (5) and ursolic acid (6) in addition to β-sitosterol (7) and benzoic acid (8) has been isolated from the leaves of Lantana montevidensis. Their chemical structures were elucidated by spectroscopic analysis and by comparison with the literature data and/or authentic samples. Compound 1 showed moderate to weak antibacterial activity against Staphylococcus aureus and Escherichia coli.

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