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Natural Product Research
Formerly Natural Product Letters
Volume 28, 2014 - Issue 10
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Articles

Sensitisation of ovarian cancer cells to cisplatin by flavonoids from Scutellaria barbata

Jie LiKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan430071, P.R. China
,
Yun WangKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan430071, P.R. China
,
Jia-Chuan LeiRenmin Hospital, Wuhan University, Wuhan430060, P.R. China
,
Yang HaoKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan430071, P.R. China
,
Yuan YangKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan430071, P.R. China
,
Cheng-Xiong YangCollege of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen448000, P.R. China
&
Jian-Qing YuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan430071, P.R. ChinaCorrespondence[email protected]
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Pages 683-689 | Received 21 Oct 2013, Accepted 28 Nov 2013, Published online: 20 Dec 2013
 
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Abstract

Combination of natural components with anticancer drugs is a new strategy for cancer chemotherapy to increase antitumour responses. In this study, we investigated the sensitisation effects of nine flavonoids from Scutellaria barbata to cisplatin (CDDP) on human ovarian cancer cells. The combinations of three flavonoids with CDDP showed the synergistic effects. The intracellular reactive oxygen species and the antioxidant activity were measured. The data suggest that the synergistic effects of flavonoids with CDDP on ovarian cancer cells did not directly correlate with their redox properties, but could be associated with the positions of hydroxyl group and methoxy group of flavonoids.

Acknowledgement

This work was supported by a grant from the National Natural Science Foundation of China (Nos 31070317 and 30970294).

Notes

1. These authors contributed equally to this work.

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