Garcinielliptone FC, a polyisoprenylated benzophenone from Platonia insignis Mart., promotes vasorelaxant effect on rat mesenteric artery

Abstract

Polyisoprenylated benzophenones represent a group of chemical compounds commonly identified in Clusiaceae species and are responsible for a large amount of biological activities. In this work, the vasorelaxant effect induced by garcinielliptone FC (GFC) isolated from Platonia insignis Mart. (Clusiaceae), a monotype species from Platonia genus, was investigated. GFC promoted an endothelium-independent vasorelaxation on phenylephrine (PHE, 10^− 5 mol L^− 1)-induced vasoconstriction, but not on KCl (80 mmol L^− 1)-induced vasoconstriction, on rat superior mesenteric artery rings. In addition, a concentration-dependent decrease of PHE- or serotonin-induced cumulative concentration–response curves was observed for GFC, and a slight decrease of pD₂ value on CaCl₂-induced vasoconstriction. In a Ca²⁺-free medium, GFC interfered in calcium mobilisation from PHE (10^− 5 mol L^− 1)-sensitive intracellular stores. GFC-induced vasorelaxant effect is probably mediated by a dual effect on mobilisation of calcium intracellular stores and attenuation of transmembrane calcium influx.

Keywords::

• benzophenone
• calcium
• Clusiaceae
• garcinielliptone
• Platonia
• vasorelaxant

Acknowledgements

This work was supported by UFPI (Federal University of Piauí, Brazil), FAPEPI (Fundação de Amparo à Pesquisa do Estado do Piauí, Brazil) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil).