Nucleoside derivatives from the marine-derived fungus Aspergillusversicolor

Abstract

Four nucleoside derivatives (1–4) were isolated from the fungus Aspergillus versicolor derived from the gorgonian Dichotella gemmacea collected in the South China Sea. Their structures were elucidated by comprehensive spectroscopic method of NMR and MS analysis. All isolated metabolites were evaluated for their cytotoxicity, antibacterial activity and lethality towards brine shrimp Artemia salina. Compounds 1/2 exhibited selective antibacterial activity against Staphylococcus epidermidis with an MIC value of 12.5 μM. It should be noted that 1 and 2, whose structures were listed in SciFinder Scholar, had no associated reference. This is the first report about their isolation, structure elucidation and biological activities.

Keywords::

• marine-derived fungus
• Aspergillus versicolor
• nucleoside derivative
• transesterification
• antibacterial activity

Acknowledgements

We thank Dr Chang-Lun Shao for collection of the gorgonian samples. This work was supported by the National Natural Science Foundation of China (Nos 41130858; 81172977), the National High Technology Research and Development Program of China (863 Program) (No. 2013AA093001) and the Fundamental Research Funds for the Central Universities of China (No. 201122005).