New eudesmane-type sesquiterpenoid from Solanum lyratum with cytotoxic activity

Abstract

In our continuing effort to discover more new cytotoxic sesquiterpenoids from Solanum lyratum, one new eudesmane-type sesquiterpenoid (1, 3-keto-eudesm-9β,11-diol, named lyratol G), together with one known eudesmane-type sesquiterpenoid (2, 1β-hydroxy-1,2-dihydro-α-santonin), was obtained. The structure of the new sesquiterpenoid was elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D NMR (¹H–¹H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoids were found to exhibit significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC₅₀ values in the range of 3.1–6.9 μM.

Keywords::

• Solanum lyratum
• Solanaceae
• sesquiterpenoid
• lyratol G
• cytotoxic activity

Acknowledgements

This study was supported by the National Natural Science Foundation of China (No. 21372189). The authors are grateful to Ms Wen-Yan Wang and Li Shen (School of Pharmaceutical Science, Yantai University) for the measurements of FAB-MS, HR-FAB-MS, UV, IR and NMR spectra. The authors also gratefully acknowledge Mr Hong-Bo Wang (School of Pharmaceutical Science, Yantai University) for the bioactivity screening.