Pelopuradazole, a new imidazole derivative alkaloid from the marine bacteria Pelomonas puraquae sp. nov.

Abstract

One new imidazole derivative alkaloid pelopuradazole (1), together with three known alkaloids as in 3H-imidazole-4-carboxylic acid (2), 1H-pyrrole-2-carboxylic acid (3) and 2-methyl-3H-imidazole-4-carboxylic acid (4) and two known cyclo-dipeptides pelopurin A (5) and pelopurin B (6), has been isolated from the marine bacterium Pelomonas puraquae sp. nov. Pelopuradazole (1) was a new imidazole derivative alkaloid, while compounds 2, 3, 5 and 6 were firstly obtained as natural products. Compounds 1–6 were isolated from P. puraquae sp. nov. for the first time.

Keywords::

• marine bacteria
• Pelomonas puraquae sp. nov.
• Pelopuradazole
• alkaloid
• cyclic dipeptide

Acknowledgements

This work was supported by a grant from the National Natural Science Foundation of China [No. 81001370] and Collaborative Fund of marine Key Laboratory of marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences [LMB101002]. The authors also thank Professor Chang-Sheng Zhang of South China Sea Institute of Oceanology, Chinese Academy of Sciences for identification of the specimen.