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Natural Product Research
Formerly Natural Product Letters
Volume 28, 2014 - Issue 16
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Short Communication

Three alkaloids from Reineckia carnea herba and their antitussive and expectorant activities

Jun WangDevelopment and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, P.R. China
,
Na HanDevelopment and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, P.R. China
,
Yao WangDevelopment and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, P.R. China
,
Yichun WangDevelopment and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, P.R. China
,
Zhihui LiuDevelopment and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, P.R. China
,
Yu Wang 463 Military Hospital of China, Shenyang110042, P.R. China
&
Jun YinDevelopment and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, P.R. ChinaCorrespondence[email protected]
 show all
Pages 1306-1309 | Received 27 Oct 2013, Accepted 01 Mar 2014, Published online: 31 Mar 2014
 
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Abstract

Three alkaloids, (3-chloro-2-hydroxypropyl) trimethylammonium chloride (1), p-(acetylamino)-phenol (2) and 4,4′-diacetamidodiphenyl ether (3), were isolated from Reineckia carnea herba. Their structures were determined by detailed analysis of their 1D and 2D NMR spectra and MS. Compounds 1 and 3 were new natural products. Compound 2 was isolated for the first time from the Reineckia genus. Compound 1 displayed significant in vivo antitussive and expectorant activities.

Acknowledgement

This work was financially supported by grants from the National Natural Science Foundation of China [grant number 8100694].

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