A new luteolin triglycoside from Ficus ischnopoda leaves

Abstract

A new triglycoside flavone, luteolin-4′-O-α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranoside (1) was isolated from the leaves of Ficus ischnopoda, together with five known flavonoids (2–6) and seven known lignans (7–13). Their structures were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data. Compounds 1–13 were reported in this plant for the first time. Compounds 1 and 3–6 exhibited significant anti-HSV-1 activity in vitro.

Keywords::

• Ficus ischnopoda
• Moraceae
• luteolin triglycoside
• anti-HSV-1

Acknowledgements

This work was financially supported by the Program of the Committee of Science and Technology of Shanghai (11495801500). We are grateful to Dr Li-Hong Wu (Shanghai R&D Centre for Standardization of Chinese Medicines) for identifying the plant materials, and to Peng-Fei Li, Qing Liu and Song-Shan Shi (Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine) for measuring HR-ESI-MS and NMR measurements, thanks are also given to Prof. Pei Zhou (Fudan University) for bioactive tests.