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Natural Product Research
Formerly Natural Product Letters
Volume 28, 2014 - Issue 18
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Short Communication

The antibacterial activity of phytochemically characterised fractions from Folium Syringae

Zhengyuan ZhouDepartment of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang110016, P.R. China
,
Na HanDepartment of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang110016, P.R. China
,
Zhihui LiuDepartment of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang110016, P.R. China
,
Jinling WangDepartment of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang110016, P.R. China
,
Huanzhang XiaDepartment of Microbiology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang110016, P.R. China
,
Dezu MiaoShandong Reyoung Pharmaceutical Co., Ltd., Yiyuan256100, China
,
Wei LiShandong Reyoung Pharmaceutical Co., Ltd., Yiyuan256100, China
&
Jun YinDepartment of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang110016, P.R. ChinaCorrespondence[email protected]
 show all
Pages 1495-1498 | Received 11 Dec 2013, Accepted 04 Apr 2014, Published online: 08 May 2014
 
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Abstract

To identify the most active antimicrobial fraction of Folium Syringae, four common pathogens were used in an in vitro screening. The results indicated that the combination of the 30% and 60% ethanol fraction (FSC) obtained from the water extraction was the most active fraction with a minimal inhibitory concentration of 0.65 mg mL− 1. FSC was also found to be able to protect mice from a lethal infection of Staphylococcus aureus at clinical dosage (0.2 g kg− 1) with a survival rate of 83.3%. The antibacterial activity of FSC was then tested using the serum pharmacology method which revealed that FSC exhibits a more long-lasting activity than the positive control (levofloxacin hydrochloride). The main components were confirmed to be iridoid glycosides and flavones by HPLC–MS analysis.

Acknowledgement

This work was supported by grants from the National Natural Science Foundation of China [81274040].

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