Abstract
The paper describes a new pathway for an efficient synthesis of natural and bioactive drimanic compounds ( − )-pereniporin B (1) and ( − )-cinnamosmolide (2) from ketodiol 7, an intermediate obtained before from accessible labdane diterpenoid (+)-larixol (3). The key step involves allylic bromination of acetate 8 with N-bromosuccinimide. The in vitro antimicrobial and antifungal activities of all compounds are also reported. Their structures were confirmed by both spectroscopic data and chemical transformations.
Acknowledgements
The support from the Project No. 264115 (STREAM) in the frame of EU funded FP7-REGPOT-2010-1 call is acknowledged by the authors from the ‘Petru Poni Institute’.