Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa

Abstract

Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.

Keywords::

• bromopyrrole alkaloids
• antiproliferative
• protein kinase
• neurodegenerative disorders

Acknowledgements

We thank Prof. J. C. Braekman (ULB, Belgium) for giving us the sample of S. flabelliformis and Prof. Dr van Soest (University of Amsterdam, the Netherlands) for its identification.

Additional information

Funding

S.S.E. acknowledges the Egyptian Government (Ministry of High Education) for a doctoral scholarship and the University of Düsseldorf for a postdoctoral fellowship. P.P. acknowledges BMBF for financial support. We acknowledge the support of the European Union 7th Framework Program Knowledge-Based Bio-economy [grant number FP7-KBBE] – BlueGenics 2012 grant, including a postdoctoral fellowship.