In vivo gastroprotective effect of xyloccensin-E and xyloccensin-I from Xylocarpus molluccensis in rats

Abstract

Anti-ulcer activities of xyloccensin-E and xyloccensin-I were investigated in various ulcer models in Sprague-Dawley rats. The effects and the mechanism of action of both compounds for anti-secretory and cytoprotective activities were also studied. Both these active molecules improved the depleted levels of mucin and consequently inhibited the formation of erosions in a pyloric ligated ulcer model. Furthermore, xyloccensin-E and xyloccensin-I inhibited H⁺K⁺-ATPase activity in vitro confirming their anti-secretory activity. In conclusion, xyloccensin-E and xyloccensin-I were found to possess anti-ulcerogenic activity which might be due to their anti-secretory activity and subsequent strengthening of the defensive mechanism.

Keywords::

• gastric ulcer
• proton pump
• xyloccensin E and xyloccensin I

Acknowledgements

Financial assistance by the Ministry of Earth Sciences, Government of India, New Delhi, India is gratefully acknowledged. The author (VL) Emeritus Scientistship and Vaibhav Mishra, Senior research fellow gratefully acknowledge the HRDG, CSIR, New Delhi for providing financial support which helped in compiling this work. Thanks are also due to Dr M.N. Srivastava for the collection of the plant.

Notes

^1. Present address: Department of Biochemistry, King George's Medical University, Lucknow 226003, India